**Core Concept**
Hepatic amoebiasis, caused by *Entamoeba histolytica*, is a serious infection that requires prompt and effective treatment to prevent complications and mortality. The pathogenesis involves the invasion of liver tissue by the amoeba, leading to abscess formation and potential rupture.

**Why the Correct Answer is Right**
The treatment of choice for hepatic amoebiasis is a combination of antiamoebic medications, specifically metronidazole, which targets the amoeba's energy metabolism by inhibiting the enzyme pyruvate:ferredoxin oxidoreductase. This leads to the destruction of the amoeba and resolution of the infection. Additionally, luminal amoebicides such as paromomycin or iodoquinol are used to eliminate any remaining amoeba from the intestinal lumen, reducing the risk of recurrent infection.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it does not address the specific treatment of hepatic amoebiasis.
**Option B:** This option is incorrect as it is a misinterpretation of the treatment, which should involve a combination of antiamoebic medications, not just a single agent.
**Option C:** This option is incorrect as it refers to a treatment for a different condition, and is not relevant to hepatic amoebiasis.

**Clinical Pearl / High-Yield Fact**
It's essential to note that metronidazole should not be given orally for hepatic amoebiasis, as it may exacerbate the condition. Instead, it should be administered parenterally.

**Correct Answer: C. Metronidazole and a luminal amoebicide.