True statement about Ribozyme
Correct Answer: RNA molecular that acts catalytically to change itself or another RNA molecule
Description: The substrate for ribozymes is often an RNA molecule, and it may even be pa of the ribozyme itself Ribozymes vary greatly in size. A self-splicing group I intron may have more than 400 nucleotides. The hammerhead ribozyme consists of two RNA strands with only 41 nucleotides in all. As with protein enzymes, the three-dimensional structure of ribozymes is impoant for function. Ribozymes are inactivated by heating above their melting temperature or by addition of denaturing agents or complementary oligonucleotides, which disrupt normal base-pairing patterns. Ribozymes can also be inactivated if essential nucleotides are changed. Example: Hammerhead ribozyme: These segments are called hammerhead ribozymes because their secondary structures are shaped like the head of a hammer. The hammerhead ribozyme is a metalloenzyme; Mg+2 ions are required for activity. The phosphodiester bond at the site of self-cleavage is indicated by an arrow In Tetrahymena, the pre-rRNA molecule contains an intron that is removed by self-splicing (in the presence of guanosine, GMP, GDP or GTP) without the need for involvement of any protein. This was the first ribozyme discovered but many have since been repoed.
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