**Core Concept**
Cyclooxygenase-2 (COX-2) is an enzyme involved in the synthesis of prostaglandins, which play a crucial role in inflammation, pain, and fever. COX-2 is specifically induced in response to tissue damage or inflammation, unlike COX-1 which is constitutively expressed in most tissues.

**Why the Correct Answer is Right**
COX-2 is responsible for the production of prostaglandins, particularly PGE2, which is a key mediator of inflammation and pain. This enzyme is induced in response to inflammatory stimuli, such as cytokines and growth factors, and is primarily expressed in cells involved in the inflammatory response. The selective inhibition of COX-2 has become a therapeutic strategy for managing pain, inflammation, and other conditions associated with this enzyme.

**Why Each Wrong Option is Incorrect**
**Option A:** Not a true statement about COX-2.
**Option B:** Incorrect, as COX-2 is primarily involved in inflammation and pain, not in the regulation of blood pressure.
**Option C:** Not accurate, as COX-2 is not responsible for the production of thromboxane A2.

**Clinical Pearl / High-Yield Fact**
COX-2 inhibitors are a class of nonsteroidal anti-inflammatory drugs (NSAIDs) that selectively target COX-2, reducing the risk of gastrointestinal side effects associated with non-selective NSAIDs.

**Correct Answer: D.**