TRUE statement about achalasia cardia is:
Correct Answer: Loss of ganglion cells within the esophageal myenteric plexus
Description: Achalasia is a rare disease It is caused by loss of the ganglion cells within the esophageal myenteric plexus With long-standing disease, viual aganglionosis is noted. Pathology: Impaired deglutitive LES relaxation and absent peristalsis. It is believed that cause of ganglion cell degeneration in achalasia is an autoimmune process attributable to a latent infection with human herpes simplex virus 1 combined with genetic susceptibility. Ref: Harrison, Edition-18, Page-2431.
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