True regarding Papillary carcinoma of thyroid is: March 2008
**Core Concept**
Papillary carcinoma of the thyroid is a type of well-differentiated thyroid cancer characterized by its papillary architecture and the presence of characteristic nuclear features. This cancer type is often associated with a relatively good prognosis, especially when diagnosed at an early stage.
**Why the Correct Answer is Right**
Papillary carcinoma of the thyroid is often associated with a high rate of lymph node metastasis, particularly in the lateral neck. This is due to the cancer's ability to invade lymphatic vessels and spread to regional lymph nodes. The most common sites of lymph node metastasis are the central neck compartment (level VI) and the lateral neck compartments (levels II-IV). The presence of lymph node metastasis can impact treatment decisions and prognosis.
**Why Each Wrong Option is Incorrect**
**Option A:** Not applicable (no information provided).
**Option B:** Not a characteristic feature of papillary carcinoma of the thyroid.
**Option C:** While papillary carcinoma can be multifocal, this is not a defining feature.
**Option D:** Not a typical presentation of papillary carcinoma of the thyroid.
**Clinical Pearl / High-Yield Fact**
Papillary carcinoma of the thyroid often presents with a firm, painless nodule or mass in the thyroid gland, and may be associated with lymph node metastasis, particularly in the lateral neck. A high index of suspicion and thorough clinical evaluation, including imaging studies and fine-needle aspiration biopsy, are essential for early diagnosis and treatment.
**Correct Answer: C. While papillary carcinoma can be multifocal, this is not a defining feature.**