True regarding multiple myeloma are all except
**Question:** True regarding multiple myeloma are all except
A. Multiple myeloma is a plasma cell disorder
B. It is a common cause of bone lesions
C. It is associated with autoimmune diseases
D. It is a rare disease in children
**Correct Answer:** C. It is associated with autoimmune diseases
**Core Concept:** Multiple myeloma is a plasma cell disorder characterized by the proliferation of monoclonal plasma cells in the bone marrow, leading to impaired bone marrow function and production of abnormal antibodies. It is typically a disease affecting older adults and is classified as a type of lymphoproliferative disorder.
**Why the Correct Answer is Right:** Multiple myeloma is not typically associated with autoimmune diseases. In contrast, autoimmune disorders are characterized by immune system dysfunction and the attack on self-tissues, which is not the case in multiple myeloma.
**Why Each Wrong Option is Incorrect:**
A. Multiple myeloma is a plasma cell disorder, which is a type of lymphoproliferative disorder, not related to autoimmune diseases.
B. Multiple myeloma can lead to bone lesions due to excessive osteoclast activation, but it is not a common cause of bone lesions as it is a rare disease.
D. Multiple myeloma is a disease affecting older adults; however, it is a rare disease in children.
**Why Each Wrong Option is Incorrect:**
A. Multiple myeloma is a plasma cell disorder, which is a type of lymphoproliferative disorder, not related to autoimmune diseases.
B. Multiple myeloma can lead to bone lesions due to excessive osteoclast activation, but it is not a common cause of bone lesions as it is a rare disease.
C. Multiple myeloma is a disease affecting older adults; however, it is a rare disease in children.
**Clinical Pearl:** While multiple myeloma is a relatively rare disease, it is essential for clinicians to recognize its clinical features and differentiate it from other bone lesions caused by underlying autoimmune diseases. This distinction is crucial for appropriate diagnosis, treatment, and prognosis.