True regarding male breast Ca?
Correct Answer: Estrogen receptor positive
Description: Ans is B (Estrogen receptor positive), Male Breast cancer Breast cancer in men is a rare disease; less than 1% occurs in men. The average age is about 60 yrs - older than the most common presenting age in women. Gynecomastia is seen preceding or accompanying the breast cancer in about 20% of cases. The risk of male breast cancer is related to an increased lifelong exposure to estrogen (as with female breast cancer) or to reduced androgen. The strongest association is in men with Klinefelter's syndrome (XXY) who have a 14- to 50-fold increased risk of developing male breast cancer. Also, men who carry a BRCA1, or paicularly a BRCA2 mutation, have an increased risk of developing breast cancer. The following conditions have been repoed to be associated with an increased risk of breast cancer in men: - chronic liver disorders, such as cirrhosis, chronic alcoholism, schistosomiasis; - a history of mumps orchitis, undescended testes, or testicular injury; and - feminization, genetically or by environmental exposure - radiation exposure All known histopathologic types of breast cancer have been described in men with infiltrating ductal carcinoma being most common (about 70%). A majority of male breast cancers are ER/PR positive and the percentage positive is greater than for female breast cancer. As for women, stage is the predominant prognostic indicator, and most studies repo that stage for stage, men with breast cancer have the same outcome following treatment as women with breast cancer. Overall, men do worse because of the advanced stage of their cancer at the time of diagnosis. Treatment consists of modified radical mastectomy in operable patients. The use of postmastectomy radiation therapy follows the same guidelines as for female breast cancer. Similarly, the use of systemic therapy follows the same guidelines as for women with postmenopausal breast cancer. Tamoxifen is the mainstay for adjuvant systemic therapy in ER-positive male breast cancer. Metastatic breast cancer in men is treated identically to metastatic disease in women* Note that: About Gynaecomastia Devita's Oncology writes? "In contrast, gynecomastia alone does not appear to be a risk factor." Whereas Schwaz writes? "Male breast cancer is preceded by gynecomastia in 20% of men."
Category:
Surgery
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