True regarding chronic pancreatitis is
**Core Concept**
Chronic pancreatitis is a progressive inflammatory disease of the pancreas characterized by irreversible damage to the pancreatic tissue, leading to impaired exocrine and endocrine function. This condition is often associated with chronic abdominal pain, malnutrition, and diabetes mellitus.
**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology of chronic pancreatitis. In this condition, the pancreatic ducts become obstructed due to fibrosis and inflammation, leading to recurrent episodes of pancreatitis. This results in the activation of pancreatic enzymes within the pancreas, causing autodigestion of the gland and further inflammation. The loss of pancreatic tissue and function leads to malabsorption of fats and proteins, and impaired glucose regulation.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because chronic pancreatitis is not primarily caused by a viral infection. While viral infections can trigger acute pancreatitis, chronic pancreatitis is typically caused by a combination of genetic, environmental, and lifestyle factors.
**Option B:** This option is incorrect because chronic pancreatitis is not characterized by an increase in pancreatic enzyme production. Instead, the damage to the pancreas leads to a decrease in enzyme production and an imbalance in enzyme secretion.
**Option C:** This option is incorrect because chronic pancreatitis is not typically associated with a significant increase in pancreatic cancer risk. While there is an increased risk of pancreatic cancer in patients with chronic pancreatitis, it is not a direct consequence of the condition.
**Clinical Pearl / High-Yield Fact**
The " Cambridge score" is a useful tool for assessing the severity of chronic pancreatitis based on the presence of certain clinical and radiological features. A score of 2 or more indicates severe disease.
**Correct Answer: B. Impaired exocrine function is the hallmark of chronic pancreatitis.**