True regarding agglutination reaction are all except: September 2007
Correct Answer: It is less sensitive than precipitation reaction for detecting antibodies.
Description: Ans. A: It is less sensitive than precipitation reaction for detecting antibodies Agglutination is a two-step reaction. Same principles governs agglutination and precipitation, but agglutination reaction is more sensitive than precipitation reaction for detecting antibodies. The primary reaction is the binding of the Fab poion of antibody to antigenic determinants on the paiculate antigen. The secondary reaction is the result of the cross-linking by multivalent antibodies, of the paicles of multivalent antigen to form aggregates. The foregoing two-component system can in ceain instances be enhanced by the addition of a third component, complement (C'). This is exemplified by the reaction of immune hemolysis, in which the antibody "sensitizes" erythrocytes which are then lysed by complement. The most obvious clinical application of agglutination is blood-typing; erythrocyte blood group surface antigens (e.g., the ABO blood group factors) react with antibody that is specific for these allo-antigens to produce agglutination. The cross- matching of blood depends upon this technique. The surface antigens of bacteria also react with appropriate antibodies to produce agglutination. A patient's serum can be tested for the presence of antibody to known antigens of ceain bacteria (e.g., Salmonella typhi), giving diagnostically significant information.
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Microbiology
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