True increase in islet cella) Nesidioblastomab) Type II DMc) Insulinomad) Pancreatitis
Correct Answer: ac
Description: Also known as persistent hyperinsulinemic hypoglycemia of infancy. Characterized by diffuse hyperfunction of pancreatic beta cells with enlargement of their nuclei. Neither the beta cell proliferation rate nor the overall beta cell mass is increased.
Clinical Features
Early recognition of congenital hyperinsulinism is critical because, if untreated, profound hypoglycemia may lead to brain damage.
Babies may be described as jittery, floppy, or lethargic; seizures are common.
Diagnosis
Inappropriately elevated insulin in the setting of hypoglycemia, along with the need for continuous glucose infusion (<15 mg/kg/min) to maintain normoglycemia confirms the diagnosis.
Pancreatic venous sampling is used to make the diagnosis.
Treatment
Continuous glucose administration with suppression of insulin secretion by diazoxide or somatostatin.
Operation is necessary in more than two thirds of cases.
Treatment consists of near total (95-98%) pancreatectomy.
Category:
Surgery
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now