True about toxoplasmosis is all except ?
Correct Answer: IgG antibodies are diagnostic in Congenital toxoplasmosis
Description: Ans. is 'b i.e., IgG Antibodies are diagnostic in congenital Toxoplasmosis The presence of IgM (which does not cross placenta) in the infant's circulation is diagnostic. Specific IgG in the infant's circulation may be of maternal origin or due to infection. Diagnosis of congenital toxoplasmosis ? 1. PCR . PCR of the amniotic fluid to detect the B1 gene of the parasite has replaced fetal blood sampling. 2. Serology . The presence of IgM in infant's circulation is diagnostic of congenital infection. . The double - sandwitch IgA - ELISA is more sensitive than the IgM- ELISA for detecting congenital infection in the fetus and newborn - Harrison 16th - 1309 . Specific IgG in infant's circulation may be of maternal origin or due to infection. Testing of infant's blood at 2 monthly intervals will show whether the IgG antibody level is decreasing. At 6 - 10 months the infant's circulation should not contain maternal IgG and therefore persistence of IgG beyond 6 -10 months is indicative of infection in the infant. About other options . In immunocompetant adults, 80-90% infections are asymptomatic. . Toxoplasmosis is an anthropozoonoses ie : infection transmitted to man from veebrate animals. . Encephalitis is a rare complication in immunocompetant patients.
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