True about TB in HIV infection -a) Less susceptibility to ATTb) Same susceptibility to ATTc) Faster progression of ATTd) TB more common in AIDS
Correct Answer: bd
Description: Treatment of T.B. in H.I.V. patient
In general, the standard treatment regimens are equally efficacious in HIV negative and HIV positive patients.
Therapy for T.B. is generally the same in the HIV infected patient as in the HIV negative patient.
Initiation of combination antiretroviral therapy and/or ante :
T.B. therapy may be associated with clinical deterioration due to immune reconstitution inflammatory syndrome (IRIS) reactions.
These are most common in patients initiating both treatment at the same time and may occur as early as 1 week after initiation of therapy and are seen snore frequently in patients with advanced HIV disease.
For these reasons it is often recommended that initiation of combination antiretroviral therapy (CART) be delayed in patients until 2-8 weeks following the initiation of treatment for T.B.
Drug interaction b/w CART and rifamycin
Due to pharmacokinetic interactions, an adjusted dose of rifabutin should be substituted for rifampin in patients receiving HIV protease inhibitors or nonnucleoside reverse transcriptase inhibitors.
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