True about silent mutation in gene
**Core Concept**
A **silent mutation** is a type of genetic mutation where the alteration in the DNA sequence does not result in a change in the amino acid sequence of the protein. This occurs due to the degeneracy of the **genetic code**, where more than one **codon** can code for the same **amino acid**.
**Why the Correct Answer is Right**
Since the question is incomplete, let's discuss the general concept. A silent mutation happens when a **point mutation** occurs, but the new codon still codes for the same amino acid as the original codon. This is possible because of the **wobble hypothesis**, which allows some flexibility in the base pairing between **tRNA** and **mRNA**.
**Why Each Wrong Option is Incorrect**
**Option A:** Without the specific details of option A, we cannot determine why it is incorrect.
**Option B:** Similarly, option B's incorrectness cannot be assessed without more information.
**Option C:** And option C's wrongness is also unknown due to lack of context.
**Option D:** The same applies to option D.
**Clinical Pearl / High-Yield Fact**
Remember, **silent mutations** do not change the **amino acid sequence**, but they can still have effects on gene function by altering **splicing sites** or **gene regulation**.
**Correct Answer:** D. No change in amino acid sequence