Pharmacology True about pioglitazone are all except: A Metabolized in the liver by CYP3A4 B Selective agonist for the nuclear peroxisome profilerator activated receptor gamma C It causes transcription of gene for carbohydrate and fat metabolism in the absence of insulin D It should be avoided in a patient with cardio-vascular disease 💡 Explanation True about pioglitazone are all except: ✓ Correct Answer: C. It causes transcription of gene for carbohydrate and fat metabolism in the absence of insulin