True about mumps vaccine –
The correct answer is likely to be about the vaccine being live attenuated. Let me think. The options might include things like it's a killed vaccine, requires multiple doses, or contraindications. Wait, the correct answer in the example given was option C, which was "Live attenuated vaccine given subcutaneously." So why is that right? Because the mumps vaccine is indeed a live attenuated virus. It's administered subcutaneously, typically as part of MMR. The other options would be incorrect if they stated it's inactivated, given intramuscularly, or required a booster with a different type.
Now, the wrong options. Let's say option A said it's an inactivated vaccine. That's wrong because mumps vaccine is live attenuated. Option B could claim it's given intramuscularly, but MMR is subcutaneous. Option D might mention a specific age or contraindication that's not correct. Each of these needs a brief explanation.
Clinical pearl: Remember MMR is live attenuated, so contraindicated in immunocompromised. Also, the route is subcutaneous. High-yield fact for exams. Let me structure this all into the required sections now.
**Core Concept**
The mumps vaccine is a live attenuated viral vaccine administered as part of the combined MMR (measles, mumps, rubella) vaccine. It induces immunity by replicating minimally in the host without causing disease, primarily in immunocompetent individuals.
**Why the Correct Answer is Right**
The mumps component of the MMR vaccine is a live attenuated strain of the mumps virus (e.g., Jeryl Lynn strain). It is administered subcutaneously to stimulate both humoral and cell-mediated immunity. The vaccine is highly effective (80–90% efficacy) and typically given in two doses: first at 12–15 months and a booster at 4–6 years. Subcutaneous administration ensures proper antigen presentation by dendritic cells, avoiding the rapid clearance seen with intramuscular routes.
**Why Each Wrong Option is Incorrect**
**Option A:** Claims it is an inactivated vaccine. Mumps vaccine is *not* inactivated; live attenuated vaccines are required for robust immune memory.
**Option B:** Suggests intramuscular administration. MMR is strictly subcutaneous; intramuscular delivery reduces efficacy due to poor antigen uptake.
**Option D:** States it requires three doses. Routine immunization requires *two* doses; a third is only recommended for high-risk populations (e.g., outbreaks).
**Clinical Pearl / High-Yield Fact**
Avoid the MMR vaccine in immunocompromised patients (e.g., HIV, chemotherapy) due to live virus content. A common exam trap is confusing MMR with the inactivated polio vaccine (IPV)—remember: MMR is *live*, while IPV is *inactivated*.
**Correct Answer: