True about methanol poisoning is all except –
**Core Concept**
Methanol poisoning is a serious condition that occurs when methanol (also known as wood alcohol) is ingested, inhaled, or absorbed through the skin. The underlying **toxicological principle** being tested is the body's response to methanol and its metabolites. Methanol is metabolized by **alcohol dehydrogenase** to formaldehyde, which is then converted to formic acid, the primary toxic metabolite.
**Why the Correct Answer is Right**
Since the correct answer is not provided, I will explain the general mechanism of methanol poisoning. Methanol itself is not highly toxic, but its metabolites, particularly **formic acid**, are highly toxic to the **central nervous system** and can cause severe **metabolic acidosis**. The symptoms of methanol poisoning include visual disturbances, headache, and nausea, which can progress to more severe conditions such as **seizures** and **coma**.
**Why Each Wrong Option is Incorrect**
**Option A:** Without the specific option text, it's impossible to provide a detailed explanation. However, common incorrect statements about methanol poisoning might include the idea that it does not cause visual disturbances or that **fomepizole** is not used as an antidote.
**Option B:** Similarly, without the text, we can't address this directly, but incorrect options might suggest that methanol poisoning is not treated with **hemodialysis** or that **ethanol** is not used as a competitive inhibitor for **alcohol dehydrogenase**.
**Option C:** Again, lacking the specific text, a common misconception might be that methanol poisoning does not lead to **renal failure** or that **formic acid** is not the primary toxic metabolite.
**Option D:** This option might incorrectly state the role of **bicarbonate** in treatment or suggest that methanol poisoning does not cause **hypocalcemia**.
**Clinical Pearl / High-Yield Fact**
A key point to remember in methanol poisoning is the importance of early diagnosis and treatment to prevent long-term sequelae, such as blindness. **Fomepizole** and **ethanol** can be used to competitively inhibit **alcohol dehydrogenase**, reducing the formation of toxic metabolites.
**Correct Answer:**