**Core Concept:**
Metastatic calcification is a pathological process where calcium salts accumulate in soft tissues due to disturbed calcium and phosphate homeostasis. It can lead to various clinical manifestations depending on the affected organ systems.

**Why the Correct Answer is Right:**
Metastatic calcification occurs when the usual physiological process of calcium and phosphate regulation is disrupted. This can be due to elevated serum calcium or phosphate levels, decreased renal phosphate excretion, or increased intestinal phosphate absorption. These disturbances cause calcium salts to deposit in soft tissues, leading to the formation of calcified deposits.

**Why Each Wrong Option is Incorrect:**
A. False: Calcification is primarily a process occurring in bones (osteogenesis) rather than soft tissues.
B. False: While hyperphosphatemia may promote calcification, it is not the sole cause of this process.
C. False: Hypercalcemia can lead to calcification, but it is not the only condition causing this phenomenon.
D. False: Calcification occurs in soft tissues due to disturbed calcium and phosphate homeostasis, not just vitamin D deficiency.

**Clinical Pearl / High-Yield Fact:**
Metastatic calcification can result from various underlying diseases or conditions, such as:
1. Chronic kidney disease (CKD)
2. Hyperparathyroidism
3. Hypercalcemia
4. Hyperphosphatemia
5. Congenital disorders of mineral and bone homeostasis (e.g., hypophosphatasia, hypocalcemic tetany)

In summary, correct answers to questions about metastatic calcification depend on understanding the underlying causes, which can include a combination of disorders affecting calcium and phosphate homeostasis, as well as renal function.