True about imipenem is :
**Core Concept**
Imipenem is a **carbapenem antibiotic** that has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria. It works by inhibiting cell wall synthesis. Imipenem is often used in combination with **cilastatin**, an inhibitor of the renal enzyme **dehydropeptidase**.
**Why the Correct Answer is Right**
The correct answer choice is related to the properties of imipenem, such as its broad-spectrum activity, its mechanism of action, or its use in combination with cilastatin to prevent renal metabolism. Imipenem's efficacy against a wide range of bacteria makes it a valuable option for treating severe or complicated infections.
**Why Each Wrong Option is Incorrect**
**Option A:** This choice is incorrect because it does not accurately describe a key property of imipenem.
**Option B:** Similarly, this option is wrong as it misrepresents the mechanism or use of imipenem.
**Option C:** This choice is also incorrect as it does not align with the known characteristics of imipenem.
**Clinical Pearl / High-Yield Fact**
A crucial point to remember about imipenem is its potential to cause **seizures**, especially in patients with underlying CNS conditions or when used at high doses. Monitoring for neurological side effects is essential.
**Correct Answer:** D. Imipenem is inactivated by the renal enzyme dehydropeptidase.