True about Hurler’s syndrome is:
**Core Concept**
Hurler's syndrome is a rare genetic disorder caused by a deficiency of the enzyme alpha-L-iduronidase, leading to the accumulation of glycosaminoglycans (GAGs) in various tissues. This deficiency results in a range of clinical manifestations, including developmental delay, clouded corneas, and skeletal abnormalities.
**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology of Hurler's syndrome. The accumulation of GAGs, such as dermatan sulfate and heparan sulfate, leads to cellular damage and dysfunction. This is due to the inability of alpha-L-iduronidase to break down these GAGs, resulting in their accumulation and subsequent toxicity to cells.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not accurately describe the underlying pathophysiology of Hurler's syndrome. While it may be true that Hurler's syndrome is caused by a deficiency of a specific enzyme, this option does not provide any additional information about the disorder.
* **Option B:** This option is incorrect because it is a characteristic of another genetic disorder, not Hurler's syndrome. For example, Hunter's syndrome is caused by a deficiency of the enzyme iduronate-2-sulfatase, but it does not involve the accumulation of GAGs.
* **Option C:** This option is incorrect because it is a general statement that could apply to many different genetic disorders. While it is true that Hurler's syndrome is a genetic disorder, this option does not provide any specific information about the disorder.
**Clinical Pearl / High-Yield Fact**
A key feature of Hurler's syndrome is the presence of clouded corneas, which can be detected on physical examination. This is an important clinical finding that can help diagnose the disorder.
**Correct Answer: D.**