**Core Concept**
Granulosa cell tumors are a type of sex cord-stromal tumor that arise from the granulosa cells of the ovary, which are responsible for producing estrogen. These tumors can be either adult or juvenile types and are known for their potential to produce estrogen, leading to various clinical manifestations.
**Why the Correct Answer is Right**
Granulosa cell tumors are known for their characteristic histological features, including the presence of Call-Exner bodies, which are small, rounded, or oval spaces surrounded by granulosa cells. These tumors can produce estrogen, leading to symptoms such as vaginal bleeding, endometrial hyperplasia, and even feminization in men. The tumor cells typically express estrogen receptors and can be treated with hormonal therapy.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because granulosa cell tumors are indeed known to produce estrogen, leading to various clinical manifestations.
**Option B:** This option is incorrect because granulosa cell tumors are typically estrogen-producing tumors, and their histological features include the presence of Call-Exner bodies.
**Option C:** This option is incorrect because granulosa cell tumors are not typically associated with androgen production.
**Clinical Pearl / High-Yield Fact**
A key clinical feature of granulosa cell tumors is their potential to produce estrogen, leading to symptoms such as vaginal bleeding and endometrial hyperplasia. It is essential to consider the possibility of a granulosa cell tumor in any patient with a pelvic mass and estrogen-related symptoms.
**Correct Answer: C.**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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