True about Gardner’s syndrome is except
**Core Concept**
Gardner's syndrome is a variant of **familial adenomatous polyposis (FAP)**, characterized by the presence of multiple **colonic polyps**, **osteomas**, and **soft tissue tumors**. It is an autosomal dominant disorder caused by mutations in the **APC gene**.
**Why the Correct Answer is Right**
The correct answer would be related to the characteristic features of Gardner's syndrome, which include **colonic polyps** that have a high potential for malignant transformation, **osteomas** (especially of the mandible), and various **soft tissue tumors** like **desmoid tumors**.
**Why Each Wrong Option is Incorrect**
**Option A:** This option might be incorrect if it suggests a lack of association with FAP or does not acknowledge the presence of osteomas and soft tissue tumors.
**Option B:** Similarly, this could be wrong if it denies the hereditary nature or the role of the APC gene.
**Option C:** This option might be incorrect if it fails to recognize the risk of colorectal cancer or the presence of extracolonic manifestations.
**Option D:** Without the specific details of each option, we can infer that the incorrect options would not align with the known characteristics of Gardner's syndrome.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that Gardner's syndrome is a subtype of FAP with extracolonic manifestations, and patients have a nearly 100% risk of developing **colorectal cancer** if left untreated. Early diagnosis and management are crucial.
**Correct Answer:**