True about fibronectin nephropathy are all except-
**Core Concept**
Fibronectin nephropathy is a rare cause of nephrotic syndrome characterized by the deposition of fibronectin in the glomeruli, leading to proteinuria and renal dysfunction. This condition is often associated with conditions such as autoimmune disorders, malignancies, and chronic infections.
**Why the Correct Answer is Right**
Fibronectin nephropathy typically presents with heavy proteinuria, hypoalbuminemia, and hyperlipidemia. The pathophysiology of this condition involves the abnormal deposition of fibronectin in the glomerular basement membrane, which disrupts the normal filtration barrier and allows large molecules to pass through into the urine. The exact mechanisms behind the deposition of fibronectin are not fully understood, but it is thought to be related to immune complex deposition and complement activation.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because fibronectin nephropathy is a distinct clinical entity from membranous nephropathy, which is characterized by the deposition of immune complexes on the subepithelial side of the glomerular basement membrane.
* **Option B:** This option is incorrect because fibronectin nephropathy is not typically associated with hematuria, which is a common feature of conditions such as IgA nephropathy and thin basement membrane disease.
* **Option C:** This option is incorrect because fibronectin nephropathy is not typically associated with hypertension, which is a common feature of conditions such as diabetic nephropathy and hypertensive nephrosclerosis.
**Clinical Pearl / High-Yield Fact**
Fibronectin nephropathy is a rare cause of nephrotic syndrome that should be considered in the differential diagnosis of patients with heavy proteinuria and hypoalbuminemia, particularly in the context of underlying autoimmune disorders or malignancies.
**Correct Answer:** D