True about fibronectin nephropathy are all except:
**Core Concept**
Fibronectin nephropathy, also known as IgM nephropathy or membranoproliferative glomerulonephritis (MPGN) type II, is a rare kidney disease characterized by the accumulation of immune complexes and fibronectin in the glomeruli. This condition often presents with hematuria, proteinuria, and progressive renal failure.
**Why the Correct Answer is Right**
Fibronectin nephropathy is a type of MPGN that is associated with the deposition of fibronectin and complement components in the glomeruli. The disease is often seen in children and young adults, and it is characterized by the presence of IgM and C3 deposits in the glomeruli. The pathogenesis of fibronectin nephropathy involves the activation of the complement system, leading to the formation of immune complexes and the deposition of fibronectin in the glomeruli.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because fibronectin nephropathy is not typically associated with diabetes mellitus. Diabetes mellitus is more commonly associated with diabetic nephropathy, which is characterized by the accumulation of extracellular matrix proteins in the glomeruli.
**Option B:** This option is incorrect because fibronectin nephropathy is not typically associated with systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disease that can affect multiple organs, including the kidneys, but it is more commonly associated with lupus nephritis, which is characterized by the deposition of immune complexes and complement components in the glomeruli.
**Option C:** This option is incorrect because fibronectin nephropathy is not typically associated with membranous nephropathy. Membranous nephropathy is a type of kidney disease that is characterized by the deposition of immune complexes on the subepithelial side of the glomerular basement membrane.
**Option D:** This option is incorrect because fibronectin nephropathy is not typically associated with minimal change disease. Minimal change disease is a type of kidney disease that is characterized by the loss of foot processes in the podocytes and the presence of proteinuria.
**Clinical Pearl / High-Yield Fact**
Fibronectin nephropathy is a rare but important cause of kidney disease in children and young adults. It is characterized by the presence of IgM and C3 deposits in the glomeruli, and it often presents with hematuria and proteinuria.
**Correct Answer:** D. Minimal change disease