**Core Concept**
The question is testing knowledge of DNA reconstruction technologies, specifically the ability to differentiate between various methods used to sequence or reconstruct DNA molecules. This involves understanding the underlying mechanisms and applications of these technologies.

**Why the Correct Answer is Right**
The correct answer is **CRISPR-Cas9**, a gene editing tool that allows for precise modifications to the genome by targeting specific sequences of DNA. This is achieved through the use of a guide RNA (gRNA) that recognizes the target sequence, and the Cas9 enzyme that cleaves the DNA at that site, allowing for the introduction of new genetic material. This technology has revolutionized the field of genetics and has numerous applications in basic research, disease modeling, and gene therapy.

**Why Each Wrong Option is Incorrect**
**Option A:** **DNA sequencing by Sanger method** is an older technology used for determining the order of nucleotides in a DNA molecule. While it is still used in some applications, it is not a DNA reconstruction technology like CRISPR-Cas9.

**Option B:** **DNA microarray** is a technique used for analyzing the expression levels of thousands of genes simultaneously. It is not a method for reconstructing DNA molecules.

**Option C:** **Polymerase chain reaction (PCR)** is a laboratory technique used to amplify specific DNA sequences. While it is a powerful tool for studying DNA, it is not a method for reconstructing DNA molecules.

**Clinical Pearl / High-Yield Fact**
One key aspect to remember when working with CRISPR-Cas9 is that the gRNA must be designed carefully to avoid off-target effects, where the Cas9 enzyme mistakenly cuts the DNA at unintended locations.

**Correct Answer:** C.