True about CF-
**Core Concept**
Cystic Fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene, leading to abnormal chloride ion transport across epithelial membranes. This results in thick, sticky mucus production that affects various organs, particularly the lungs and pancreas.
**Why the Correct Answer is Right**
The correct answer involves the pathophysiology of CF, which is characterized by defective CFTR protein function. Normally, CFTR acts as a chloride channel, allowing chloride ions to move across the cell membrane. In CF, mutations in the CFTR gene disrupt this process, leading to reduced chloride secretion into the airway surface liquid. This decrease in chloride concentration causes water to be reabsorbed into the body, resulting in thick, dehydrated mucus that clogs airways and traps bacteria.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not address the underlying pathophysiology of CF.
**Option B:** This option is incorrect because it is too vague and does not provide a specific mechanism related to CF.
**Option C:** This option is incorrect because it refers to a different respiratory condition, not CF.
**Clinical Pearl / High-Yield Fact**
Cystic Fibrosis is a classic example of a genetic disorder with a dominant mode of inheritance, meaning a single copy of the mutated gene is enough to cause the condition.
**Correct Answer: Not Provided**