True about Branchial cyst is: March 2013 (h)
**Core Concept**
A branchial cyst is a congenital anomaly resulting from the incomplete closure of the branchial clefts during embryonic development. It is a type of congenital neck mass that can present in various sizes and locations along the anterior border of the sternocleidomastoid muscle.
**Why the Correct Answer is Right**
Branchial cysts arise from the remnants of the second branchial cleft, which usually occurs along the anterior border of the sternocleidomastoid muscle, approximately 2-3 cm below the angle of the mandible. The cysts are lined by squamous epithelium and contain a thick, cheesy fluid. The most common presentation is a painless, slowly enlarging mass in the neck.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because branchial cysts are not typically associated with the first branchial cleft, which is a different embryological structure.
* **Option B:** This option is incorrect because branchial cysts do not usually present as a rapidly enlarging mass; they are typically slow-growing.
* **Option C:** This option is incorrect because branchial cysts are not typically lined by pseudostratified columnar epithelium; they are lined by squamous epithelium.
**Clinical Pearl / High-Yield Fact**
Branchial cysts are often confused with other congenital neck masses, such as thyroglossal duct cysts or lymphadenopathy. A thorough knowledge of embryology and anatomy is essential for differentiating these conditions.
**Correct Answer: A.** Branchial cysts arise from the remnants of the second branchial cleft.