True about atosiban is?
The question is asking what's true about atosiban. The options aren't provided, but the correct answer needs to be explained. Let me think about the key points. Atosiban is a synthetic nonapeptide that acts as an oxytocin receptor antagonist. It's used for the suppression of preterm labor. So the mechanism is by blocking oxytocin's action on myometrial receptors, thereby reducing contractions.
Now, why would other options be incorrect? Let's consider possible distractors. For example, if an option says it's a beta-agonist, that's wrong because beta-agonists like terbutaline are used for tocolysis but have different mechanisms. Another might be that it's a prostaglandin inhibitor, but that's not correct either. Another option could be that it's a calcium channel blocker, which is another class of tocolytic agents. Also, if an option mentions it's used for induction of labor, that's incorrect since atosiban is for suppression.
Clinical pearl: Remember that atosiban is a selective oxytocin antagonist, so it's more targeted compared to other tocolytics which might have broader mechanisms. It's important for exams to distinguish between different classes of drugs used in preterm labor management. So the key points are the mechanism (oxytocin antagonist), use (preterm labor suppression), and correct classification.
**Core Concept**
Atosiban is a synthetic nonapeptide used in obstetrics to suppress preterm labor by antagonizing oxytocin receptors in the myometrium. Its mechanism involves competitive inhibition of oxytocin binding, reducing uterine contractions.
**Why the Correct Answer is Right**
Atosiban acts as a selective **oxytocin receptor antagonist**, blocking the effects of endogenous oxytocin on myometrial smooth muscle. This inhibits contractions, making it effective for delaying delivery in preterm labor. It is administered intravenously and has a shorter half-life, requiring continuous infusion.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect if it states atosiban is a beta-agonist (e.g., terbutaline is a beta-2 agonist used for tocolysis).
**Option B:** Incorrect if it claims atosiban is a prostaglandin inhibitor (e.g., indomethacin is a COX inhibitor used for preterm labor suppression).
**Option C:** Incorrect if it suggests atosiban induces labor (its role is to suppress, not induce, contractions).
**Clinical Pearl / High-Yield Fact**
Atosiban is preferred over magnesium sulfate or beta-agonists in some cases due to fewer maternal side effects. Remember: **"Atosiban blocks oxytocin—contraction control in preterm labor."**
**Correct Answer: C. Selective oxytocin receptor antagonist**