True about aminoglycoside are all except ?
**Core Concept**
Aminoglycosides are a class of antibiotics that work by inhibiting bacterial protein synthesis through the binding of the 30S ribosomal subunit. This action prevents the initiation complex of the ribosome from forming, thereby inhibiting protein synthesis and ultimately leading to bacterial cell death.
**Why the Correct Answer is Right**
Aminoglycosides are potent bactericidals that have a narrow therapeutic index. They are primarily excreted by the kidneys and have a high toxicity profile, particularly nephrotoxicity and ototoxicity. Their mechanism of action involves the binding of the antibiotic to the 30S ribosomal subunit, which prevents the formation of the initiation complex and subsequent protein synthesis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because aminoglycosides do not act on the 50S ribosomal subunit, but rather on the 30S subunit.
**Option B:** This option is incorrect because while aminoglycosides can cause nephrotoxicity, they are not primarily excreted by the liver.
**Option C:** This option is incorrect because aminoglycosides are not effective against all types of bacterial infections, particularly those caused by anaerobic bacteria.
**Clinical Pearl / High-Yield Fact**
Aminoglycosides should be used with caution in patients with renal impairment, as they can accumulate to toxic levels and cause nephrotoxicity.
**Correct Answer: None**