## Core Concept
The synthesis of triacylglycerol (TAG) in adipose tissue involves the esterification of glycerol with fatty acids. This process is crucial for the storage of energy in the form of fat. The key enzymes involved in this pathway include glycerol-3-phosphate dehydrogenase, diacylglycerol acyltransferase (DGAT), and others.

## Why the Correct Answer is Right
The correct answer, , implies that the statement regarding the synthesis of triacylglycerol in adipose tissue that is not true needs to be identified. Typically, in adipose tissue, triacylglycerol synthesis starts with glycerol-3-phosphate, which is converted from glycerol by glycerol kinase or from glucose via glycolysis and glyceraldehyde-3-phosphate dehydrogenase. The process involves the acylation of glycerol-3-phosphate to form phosphatidic acid, which is then converted to diacylglycerol (DAG) and finally to triacylglycerol by DGAT.

## Why Each Wrong Option is Incorrect
- **Option A:** Typically, glycerol-3-phosphate is a key intermediate in the synthesis of triacylglycerols in adipose tissue, formed from glycerol (via glycerol kinase) or glucose metabolism. If an option suggests an alternative primary pathway not involving glycerol-3-phosphate directly, it might be incorrect.
- **Option B:** If an option mentions the role of diacylglycerol acyltransferase (DGAT) in converting DAG to TAG, it would be a correct statement regarding TAG synthesis.
- **Option C:** Similarly, if another option accurately describes a step or component in TAG synthesis, such as the involvement of fatty acyl-CoA, it would be incorrect to exclude it.
- **Option D:** Without specifics, if an option inaccurately describes a necessary step or component for TAG synthesis in adipose tissue, it would be the correct "EXCEPT."

## Clinical Pearl / High-Yield Fact
A key point to remember is that adipose tissue lacks glycerol kinase, making it reliant on glucose metabolism for glycerol-3-phosphate production. This is a critical distinction in understanding TAG synthesis in adipose tissue versus other tissues.

## Correct Answer: D.