Which of the following drug is used for treatment for steroid resistant Crohn’s disease?
**Core Concept**
Steroid-resistant Crohn's disease is a condition where patients do not respond to corticosteroids, the first-line treatment for Crohn's disease. In such cases, alternative therapies are required to induce remission and manage symptoms.
**Why the Correct Answer is Right**
The correct answer is a biologic agent, specifically an anti-tumor necrosis factor (anti-TNF) drug. These medications work by targeting and neutralizing TNF-alpha, a pro-inflammatory cytokine that plays a key role in the pathogenesis of Crohn's disease. By blocking TNF-alpha, these drugs reduce inflammation and promote healing in the gastrointestinal tract. Examples of anti-TNF drugs include infliximab and adalimumab.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is not a commonly used treatment for steroid-resistant Crohn's disease. While it may be used for other gastrointestinal conditions, it is not a first-line therapy for Crohn's disease.
**Option B:** This option is incorrect because it is an immunosuppressive agent, but it is not typically used as a first-line treatment for steroid-resistant Crohn's disease. It may be used in combination with other medications, but it is not the primary choice.
**Option C:** This option is incorrect because it is a medication used for other conditions, such as ulcerative colitis. While it may be used in some cases of Crohn's disease, it is not the primary treatment for steroid-resistant disease.
**Clinical Pearl / High-Yield Fact**
Biologic agents, including anti-TNF drugs, have revolutionized the treatment of Crohn's disease, offering new hope for patients who do not respond to traditional therapies. However, these medications can have significant side effects, and their use requires careful monitoring and management.
**Correct Answer: C. Infliximab**