Treatment of choice of Desmoid tumour is –
**Core Concept**
Desmoid tumors, also known as aggressive fibromatoses, are rare, locally aggressive, and non-metastasizing neoplasms that arise from the connective tissue. They can occur in various sites, including intra-abdominal, abdominal wall, and extremities, and have a tendency to recur after surgical resection.
**Why the Correct Answer is Right**
The treatment of choice for desmoid tumors often involves a multidisciplinary approach, but surgical excision with wide margins is generally considered the primary treatment. However, due to the high recurrence rate, adjuvant treatments are often used. The most effective adjuvant treatment for desmoid tumors is nonsteroidal anti-inflammatory drugs (NSAIDs), specifically sulindac, which has been shown to reduce tumor growth and recurrence.
**Why Each Wrong Option is Incorrect**
* **Option A:** Chemotherapy is not a first-line treatment for desmoid tumors, although it may be used in cases of unresectable or metastatic disease.
* **Option B:** Radiation therapy is not commonly used as a primary treatment for desmoid tumors, although it may be used as an adjunct to surgery in some cases.
* **Option C:** Hormonal therapy is not a standard treatment for desmoid tumors, although some studies have investigated the use of hormonal agents in the treatment of these tumors.
**Clinical Pearl / High-Yield Fact**
Desmoid tumors have a high recurrence rate after surgical resection, with rates ranging from 20% to 80% depending on the site and histology. Therefore, adjuvant treatments such as NSAIDs and radiation therapy may be used to reduce the risk of recurrence.
**Correct Answer:** C.