**Core Concept**
Desmoid tumors, also known as aggressive fibromatoses, are rare, benign, but locally aggressive neoplasms that arise from the musculoaponeurotic tissues. They are characterized by their infiltrative growth pattern and potential to cause significant morbidity due to their location and tendency to recur after surgical resection.

**Why the Correct Answer is Right**
The treatment of choice for desmoid tumors is surgical resection, with the goal of achieving complete gross resection. In cases where complete resection is not feasible, wide local excision or debulking may be considered. However, the key to successful treatment is achieving negative margins, as recurrence is more likely with positive margins. The role of adjuvant therapies, such as radiotherapy or chemotherapy, is still being investigated and is typically reserved for recurrent or unresectable disease.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because radiotherapy is not the first-line treatment for desmoid tumors, although it may be used as an adjunct in certain cases.
**Option B:** This option is incorrect because chemotherapy is not typically used as a primary treatment for desmoid tumors, although some studies have investigated its use in recurrent or unresectable disease.
**Option C:** This option is incorrect because pharmacological management with non-steroidal anti-inflammatory drugs (NSAIDs) or hormonal therapies may be considered for patients with unresectable or recurrent disease, but it is not the treatment of choice for desmoid tumors.

**Clinical Pearl / High-Yield Fact**
Desmoid tumors are more common in patients with Familial Adenomatous Polyposis (FAP) and can be associated with mutations in the APC gene. A high index of suspicion is necessary for early diagnosis and treatment to prevent complications.

**Correct Answer:** C. Surgical resection.