**Core Concept**
Pleomorphic adenoma, also known as a benign mixed tumor, is a common type of salivary gland tumor. It typically arises from the parotid gland but can also occur in other salivary glands. The treatment of choice for pleomorphic adenoma aims to completely remove the tumor while preserving surrounding tissue and function.

**Why the Correct Answer is Right**
The treatment of choice for pleomorphic adenoma is surgical excision, specifically a superficial parotidectomy or a facial nerve-sparing approach. This approach allows for the complete removal of the tumor while preserving the facial nerve and minimizing the risk of recurrence. The surgeon may also perform a facial nerve dissection to ensure the nerve is not compromised during the procedure. In some cases, a more conservative approach, such as enucleation or a limited parotidectomy, may be considered for smaller tumors.

**Why Each Wrong Option is Incorrect**
**Option A:** Radiation therapy is not typically used as a primary treatment for pleomorphic adenoma due to the risk of radiation-induced malignancy and the effectiveness of surgical excision.
**Option B:** Chemotherapy is not a standard treatment for pleomorphic adenoma, as these tumors are generally benign and do not respond well to systemic therapy.
**Option C:** Wait-and-watch approach is not recommended for pleomorphic adenoma, as these tumors have a high risk of malignant transformation and recurrence if left untreated.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that pleomorphic adenoma can recur if not completely excised, and the risk of malignancy increases with time. Regular follow-up and imaging studies are crucial to monitor for recurrence or malignant transformation.

**Correct Answer:** C. Surgical excision, specifically a superficial parotidectomy or a facial nerve-sparing approach.