**Core Concept**
Kawasaki Disease is an acute systemic vasculitis of unknown etiology, primarily affecting children, characterized by inflammation of medium-sized arteries, particularly the coronary arteries. The treatment aims to reduce inflammation and prevent coronary artery complications.

**Why the Correct Answer is Right**
Intravenous immunoglobulin (IVIG) is the treatment of choice for Kawasaki Disease due to its ability to reduce the incidence of coronary artery aneurysms and severity of illness. IVIG is thought to modulate the immune response, inhibit cytokine production, and reduce inflammation. The recommended dose is 2 grams per kilogram, administered over 10-12 hours. This is often combined with low-dose aspirin, which has anti-inflammatory and antiplatelet effects.

**Why Each Wrong Option is Incorrect**
**Option A:** Corticosteroids are not the primary treatment for Kawasaki Disease, although they may be used in certain cases, such as refractory disease or cardiac complications.
**Option B:** Plasmapheresis is not a standard treatment for Kawasaki Disease and is typically reserved for severe cases or those with significant cardiac involvement.
**Option C:** Colchicine is not a recommended treatment for Kawasaki Disease, as it has not been shown to be effective in preventing coronary artery complications.

**Clinical Pearl / High-Yield Fact**
It's essential to diagnose and treat Kawasaki Disease promptly, as delays in treatment can increase the risk of coronary artery complications, including aneurysms and long-term cardiac morbidity.

**Correct Answer: B. Plasmapheresis**