All of the following are true about glucose transport in kidney except
## Core Concept
The kidneys play a crucial role in glucose homeostasis through the reabsorption and excretion of glucose. Glucose transport in the kidneys primarily occurs in the proximal convoluted tubule (PCT) and involves specific glucose transporter proteins.
## Why the Correct Answer is Right
The correct answer involves understanding the specifics of glucose transport mechanisms in the kidney. Glucose reabsorption in the PCT is primarily facilitated by **SGLT2 (Sodium/Glucose Cotransporter 2)**, which is responsible for the majority of glucose reabsorption. The reabsorbed glucose is then transported out of the basolateral side of the tubular cells by **GLUT2 (Glucose Transporter Type 2)**. Normally, the kidney filters glucose but almost completely reabsorbs it back into the bloodstream, with little to no glucose appearing in the urine under normal conditions.
## Why Each Wrong Option is Incorrect
- **Option A:** This option is not provided, but typically, a correct statement about glucose transport in the kidney would involve SGLT2's role in the PCT.
- **Option B:** Similarly, without specifics, a correct statement might highlight GLUT2's role in basolateral glucose transport.
- **Option C:** This option is also not provided, but incorrect statements might involve misattribution of glucose transporters to wrong locations or functions.
- **Option D:** This option is stated as the correct answer but without context, we assume it presents an incorrect statement about glucose transport, such as incorrect localization of transporters or their functions.
## Clinical Pearl / High-Yield Fact
A key point to remember is that **SGLT2 inhibitors**, a class of drugs used in the treatment of type 2 diabetes, work by inhibiting glucose reabsorption in the PCT, leading to increased urinary glucose excretion and lowering blood glucose levels. This mechanism highlights the importance of SGLT2 in renal glucose handling.
## Correct Answer: D.