Type of grafts transplanted between genetically different members of the same species?
**Core Concept**
Allografts are a type of graft that involves the transfer of tissue from one individual to another of the same species but with different genetic makeup. This can be seen in organ transplantation, where a donor organ is transplanted into a recipient with a different genetic profile.
**Why the Correct Answer is Right**
The transfer of allografts requires immunosuppressive therapy to prevent rejection by the recipient's immune system. The major histocompatibility complex (MHC) molecules on the surface of the donor cells are recognized as foreign by the recipient's immune system, triggering an immune response. Allografts can be further classified into two types: isografts (between genetically identical twins) and xenografts (between different species).
**Why Each Wrong Option is Incorrect**
* **Option A:** Autografts involve the transfer of tissue within the same individual, not between genetically different members of the same species.
* **Option B:** Isografts involve the transfer of tissue between genetically identical individuals, such as twins.
* **Option D:** Xenografts involve the transfer of tissue between different species, not between genetically different members of the same species.
**Clinical Pearl / High-Yield Fact**
It's essential to note that allografts have a higher risk of rejection compared to autografts or isografts, which is why immunosuppressive therapy is necessary to prevent rejection and ensure graft survival.
**Correct Answer:** C. Allografts