**Core Concept**
Transitional Cell Carcinoma (TCC) of the bladder, also known as urothelial carcinoma, is a type of cancer that originates from the lining of the urinary bladder. Stage II TCC represents a locally advanced disease where the tumor invades the muscular layer of the bladder wall but has not spread to distant sites.

**Why the Correct Answer is Right**
In managing Stage II TCC of the bladder, the primary goal is to achieve local control of the disease while minimizing the risks of treatment-related complications. **Option C** is correct because neoadjuvant chemotherapy is recommended for patients with muscle-invasive bladder cancer, including Stage II TCC, to reduce the risk of metastasis and improve survival. This approach involves administering chemotherapy before radical cystectomy (surgical removal of the bladder) and/or radiation therapy.

**Why Each Wrong Option is Incorrect**
* **Option A:** While transurethral resection of the bladder (TURB) is a diagnostic tool for bladder tumors, it is not a definitive treatment for Stage II TCC. TURB might be performed for diagnostic purposes, but it is not sufficient for managing locally advanced disease.
* **Option B:** Radiotherapy alone is not typically recommended as the primary treatment for Stage II TCC, as it may not ensure complete tumor clearance. However, radiotherapy might be considered in combination with chemotherapy or as an adjunct to surgery in selected cases.
* **Option D:** Radical cystectomy with or without neoadjuvant chemotherapy is a standard treatment approach for Stage II TCC. However, this option does not specifically mention the role of neoadjuvant chemotherapy, which is an essential aspect of management in this stage.

**Clinical Pearl / High-Yield Fact**
It is crucial to note that the management of bladder cancer has evolved, and the role of neoadjuvant chemotherapy has been increasingly recognized in improving outcomes for patients with muscle-invasive disease. This emphasizes the importance of early diagnosis and multidisciplinary care in the management of bladder cancer.

**Correct Answer:** C. Neoadjuvant chemotherapy is recommended for patients with Stage II Transitional Cell Carcinoma of the bladder to reduce the risk of metastasis and improve survival.