True about toxoplasmosis -a) Due to ingestion of sporocyst with meatb) Due to ingestion of oocyst from cat’s faecesc) Spiramycin given in pregnancyd) Due to bite of anopheles mosquitoe) Mostly symptomatic

## **Core Concept**
Toxoplasmosis is a parasitic infection caused by *Toxoplasma gondii*, a protozoan parasite that can infect a wide range of hosts, including humans. The primary modes of transmission to humans include ingestion of oocysts from contaminated cat feces or undercooked meat containing tissue cysts.

## **Why the Correct Answer is Right**
The correct answer involves understanding the transmission and management of toxoplasmosis.
- **b) Due to ingestion of oocyst from cat's feces** is a correct statement as *T. gondii* oocysts are shed in the feces of infected cats.
- **c) Spiramycin given in pregnancy** is also correct because spiramycin is a macrolide antibiotic used to treat toxoplasmosis in pregnant women to prevent transmission to the fetus.

## **Why Each Wrong Option is Incorrect**
- **Option A:** While it's true that undercooked or raw meat can contain *T. gondii* cysts, the statement as given is not entirely accurate because it implies direct transmission via meat without specifying the need for the meat to be contaminated and undercooked.
- **Option D:** *Toxoplasma gondii* is not transmitted by the bite of an Anopheles mosquito; Anopheles mosquitoes are vectors for malaria.
- **Option E:** Mostly, toxoplasmosis is asymptomatic, especially in healthy individuals. Symptoms are more likely to occur in immunocompromised individuals and congenitally infected newborns.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that while toxoplasmosis is often asymptomatic in healthy individuals, it can cause severe disease in immunocompromised individuals, such as those with HIV/AIDS, and in fetuses if a primary infection occurs during pregnancy. The use of spiramycin in pregnancy is aimed at reducing the risk of maternal-fetal transmission.

## **Correct Answer:** C.