## Core Concept
Congenital toxoplasmosis occurs when a pregnant woman acquires a primary infection with *Toxoplasma gondii*, leading to transmission of the parasite to the fetus. This can result in serious complications, including miscarriage, stillbirth, or birth defects. The risk and severity of congenital toxoplasmosis are highest when the maternal infection is acquired during the first trimester.

## Why the Correct Answer is Right
The statement regarding congenital toxoplasmosis that is false needs to be identified based on known facts about the condition. Generally, congenital toxoplasmosis can lead to a range of outcomes, from asymptomatic infection to severe disease with significant morbidity. Key aspects include the timing of maternal infection, the presence of maternal-fetal transmission, and the potential for severe congenital infection.

## Why Each Wrong Option is Incorrect
Without specific statements for A, B, C, and D, a general approach to evaluating incorrect options regarding congenital toxoplasmosis is provided:
- **Option A:** Any statement claiming congenital toxoplasmosis only occurs with third-trimester infections would be incorrect because the risk of transmission increases with gestational age, but the severity of fetal infection is higher with first-trimester infections.
- **Option B:** A statement suggesting that congenital toxoplasmosis always results in severe symptoms at birth would be incorrect because many infants are asymptomatic at birth but may develop problems later in life.
- **Option C:** If a statement implies that maternal infection before pregnancy eliminates the risk of congenital toxoplasmosis, it would be incorrect because women who were infected before pregnancy generally have immunity, but there are rare cases of reactivation, though this typically does not lead to congenital infection.
- **Option D:** Any claim that screening for congenital toxoplasmosis is not recommended would be incorrect because guidelines often support screening pregnant women for *Toxoplasma* infection to identify those at risk.

## Clinical Pearl / High-Yield Fact
A key point to remember is that the risk of congenital toxoplasmosis can be reduced by preventive measures, such as avoiding undercooked meat, washing hands thoroughly after handling cat litter or raw meat, and screening for *Toxoplasma* infection during pregnancy. Early detection allows for the consideration of therapeutic interventions to reduce the risk of transmission.

## Correct Answer: D.