Total ATP generated by oxidation of stearic acid is
## Core Concept
The oxidation of stearic acid, a saturated fatty acid with 18 carbon atoms, involves its conversion into acetyl-CoA units, which then enter the citric acid cycle (Krebs cycle) to produce ATP, NADH, and FADH2. The complete breakdown of fatty acids to produce energy occurs through beta-oxidation, which shortens the fatty acid chain by two carbons at a time, producing one NADH and one FADH2 per cycle.
## Why the Correct Answer is Right
Stearic acid (C18) undergoes beta-oxidation to produce 8 acetyl-CoA molecules (since 18 carbons / 2 carbons per acetyl-CoA = 9 acetyl-CoA, but one cycle produces one acetyl-CoA and 8 cycles are needed to get to the last 2 carbons which directly form acetyl-CoA, thus 8 cycles). Each cycle of beta-oxidation produces 1 NADH and 1 FADH2. So, for stearic acid, there are 8 cycles, yielding 8 NADH and 8 FADH2. Additionally, 9 acetyl-CoA molecules enter the citric acid cycle, producing 9 * (3 NADH + 1 FADH2 + 1 GTP) = 27 NADH + 9 FADH2 + 9 GTP. The electrons from NADH and FADH2 are passed through the electron transport chain to produce ATP. The yield is approximately: 17 NADH * 2.5 ATP = 42.5 ATP, 17 FADH2 * 1.5 ATP = 25.5 ATP, and 9 GTP * 1 ATP = 9 ATP. This totals to 42.5 + 25.5 + 9 = 77 ATP.
## Why Each Wrong Option is Incorrect
- **Option A:** This option suggests a lower yield, possibly not accounting for all NADH, FADH2, and GTP produced during the complete oxidation of stearic acid to acetyl-CoA and subsequent entry into the citric acid cycle.
- **Option B:** Similarly, this might underestimate the ATP yield by incomplete consideration of the beta-oxidation steps and citric acid cycle products.
- **Option D:** This option might overestimate or incorrectly calculate the ATP yield, possibly by miscalculating the number of beta-oxidation cycles or the ATP yield per NADH/FADH2.
## Clinical Pearl / High-Yield Fact
A key point to remember is that the complete oxidation of fatty acids produces a significant amount of ATP, and the calculation involves understanding the stoichiometry of beta-oxidation and the citric acid cycle. For stearic acid (C18), the correct calculation yields 106 ATP (considering 8 cycles of beta-oxidation producing 8 NADH and 8 FADH2, and 9 acetyl-CoA producing 27 NADH, 9 FADH2, and 9 GTP), which seems to have been the basis for the correct answer provided.
## Correct Answer: .