## **Core Concept**
Topical steroids are a class of medications used to treat various skin conditions, including eczema, psoriasis, and dermatitis, by reducing inflammation and modulating the immune response. They work primarily by binding to specific receptors in the skin cells, which then alter the expression of various genes involved in inflammation. The most commonly used topical steroids are corticosteroids.

## **Why the Correct Answer is Right**
The correct answer, **C. Cataract and Glaucoma**, is associated with long-term or high-potency topical steroid use. Prolonged application of topical corticosteroids can lead to systemic absorption, which may cause ocular complications such as cataract formation and increased intraocular pressure (IOP), potentially leading to glaucoma. This is because corticosteroids can affect the lens of the eye, promoting cataract formation, and can also increase IOP by affecting the trabecular meshwork's ability to drain aqueous humor.

## **Why Each Wrong Option is Incorrect**
- **Option A:** While certain skin reactions and systemic effects can occur with topical steroid use, option A is not specified and therefore cannot be evaluated directly.
- **Option B:** This option is not provided, so it cannot be assessed.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that while topical steroids are effective for managing various dermatological conditions, their long-term use, especially with high-potency steroids, requires monitoring for potential systemic and local side effects, including ocular complications like cataracts and glaucoma.

## **Correct Answer:** C. Cataract and Glaucoma