Topical Mitomycin C is useful in treatment of?
Topical Mitomycin C is used in certain ocular surgeries. I think in glaucoma treatments, like after trabeculectomy to prevent scarring. Also, maybe for pterygium or conjunctival tumors. Oh, and in some cases of urothelial cancer, but that's usually systemic. Wait, the question is about topical application, so probably eye-related. Let me confirm: Mitomycin C is an antifibrotic agent. It inhibits DNA synthesis, so it prevents excessive fibrosis. In ophthalmology, it's used during surgeries to prevent the scar tissue formation that can block the outflow of aqueous humor in glaucoma. So the correct answer would be something like "Glaucoma filtration surgery" or "Trabeculectomy".
Looking at the options (though they aren't listed here), the correct answer is likely related to ocular conditions. The other options might be things like skin cancer, which uses 5-FU or imiquimod, not Mitomycin. Or maybe something like psoriasis, but that's not right. So the main use is in glaucoma surgery. Also, in some cases, it's used for pterygium excision. But the primary use is in glaucoma filtration procedures to prevent bleb failure due to scarring. So the core concept is the antifibrotic effect in ophthalmology. The wrong options would be other conditions where Mitomycin isn't topically applied. Like, for example, using it for skin conditions or systemic cancers. So the explanation should highlight that Mitomycin C is used topically in glaucoma surgery to prevent scarring, and other options are incorrect because they either use different agents or different routes.
**Core Concept**
Topical Mitomycin C is an antifibrotic agent used in ophthalmology to inhibit excessive scarring and tissue proliferation. It works by alkylating DNA, thereby suppressing fibroblast activity and collagen synthesis.
**Why the Correct Answer is Right**
Topical Mitomycin C is applied during glaucoma filtration surgeries (e.g., trabeculectomy) to prevent postoperative scarring of the filtration bleb. It is also used in pterygium excision and uveal melanoma plaque brachytherapy. Its mechanism involves inhibiting DNA replication in fibroblasts, reducing fibrosis and improving surgical outcomes.
**Why Each Wrong Option is Incorrect**
**Option A:** *Skin cancer* – Topical 5-fluorouracil or imiquimod, not Mitomycin C, is used for skin malignancies.
**Option B:** *Psoriasis* – Psoriasis is managed with topical corticosteroids, vitamin D analogs, or retinoids.
**Option C:** *Herpes zoster* – Antiviral agents like acyclovir, not Mitomycin C, treat herpes infections.
**Clinical Pearl / High-Yield Fact**
Remember **Mitomycin C = "Anti-sc