Topical mitomycin C is used to aid the following treatment:
**Core Concept**
Topical mitomycin C is an antineoplastic agent that works by inhibiting DNA synthesis, leading to cell death. It is used in ophthalmology to prevent scarring and contracture of the conjunctiva and corneal surface.
**Why the Correct Answer is Right**
Mitomycin C is applied topically to the eye to prevent scarring after surgical procedures such as pterygium excision or trabeculectomy. By inhibiting DNA synthesis, mitomycin C prevents the proliferation of fibroblasts and subsequent scarring. This is particularly useful in glaucoma surgery, where scarring can lead to failure of the trabeculectomy.
**Why Each Wrong Option is Incorrect**
**Option A:** Mitomycin C is not typically used to treat dry eye syndrome. While it may be used to prevent scarring, it is not a primary treatment for dry eye.
**Option B:** Mitomycin C is not used to treat age-related macular degeneration. Its mechanism of action is not relevant to the treatment of AMD.
**Option C:** Mitomycin C is not used to treat conjunctivitis. Its antineoplastic properties make it more suitable for use in preventing scarring after surgery.
**Clinical Pearl / High-Yield Fact**
A common side effect of topical mitomycin C is corneal ulcers, particularly in patients with pre-existing corneal disease. This is due to the toxic effects of the medication on the corneal epithelium.
**Correct Answer: C. Trabeculectomy**