TNF (alpha inhibitors) used in rheumatoid arthritis is
**Core Concept**
TNF-alpha inhibitors are a class of biologic medications used in the treatment of rheumatoid arthritis (RA) by targeting the tumor necrosis factor-alpha (TNF-alpha) cytokine, which plays a central role in the inflammatory cascade of RA.
**Why the Correct Answer is Right**
TNF-alpha inhibitors, such as adalimumab, etanercept, and infliximab, work by binding to TNF-alpha and preventing it from interacting with its receptors on the surface of immune cells. This action reduces inflammation and slows disease progression in RA patients. The mechanism of action of TNF-alpha inhibitors involves the inhibition of TNF-alpha-mediated activation of NF-κB, a transcription factor that regulates the expression of pro-inflammatory genes.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not a TNF-alpha inhibitor used in rheumatoid arthritis.
**Option B:** This option is not a TNF-alpha inhibitor used in rheumatoid arthritis.
**Option D:** This option is not a TNF-alpha inhibitor used in rheumatoid arthritis.
**Clinical Pearl / High-Yield Fact**
TNF-alpha inhibitors are effective in reducing the signs and symptoms of RA, but they can increase the risk of infections, including tuberculosis, due to their immunosuppressive effects.
**Correct Answer:** C. Infliximab