Thrombotic event is seen in all of following except –
**Core Concept**
Thrombotic events occur when there is an imbalance between pro-coagulant and anti-coagulant forces in the body, leading to the formation of a blood clot. This can be due to various factors such as hypercoagulability, endothelial damage, or stasis.
**Why the Correct Answer is Right**
Thrombotic events are commonly seen in conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and myocardial infarction (MI). These conditions can be caused by a combination of factors including genetic predisposition, trauma, surgery, immobility, and hypercoagulable states. The coagulation cascade is triggered by the exposure of tissue factor to circulating blood, leading to the activation of coagulation factors and the formation of a thrombus.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is a condition associated with thrombosis. Thrombotic events are a common complication of atrial fibrillation, particularly in patients with a history of stroke or transient ischemic attack.
**Option B:** This option is incorrect because it is a condition associated with bleeding, not thrombosis. Hemophilia A and B are genetic disorders that affect the coagulation cascade, leading to a deficiency of clotting factors VIII and IX, respectively.
**Option C:** This option is incorrect because it is a condition associated with thrombosis. Thrombotic events are a common complication of cancer, particularly in patients with a history of malignancy or metastatic disease.
**Clinical Pearl / High-Yield Fact**
It is essential to remember that thrombotic events can be prevented or treated with anticoagulant medications such as heparin, warfarin, or direct oral anticoagulants (DOACs). Early recognition and management of risk factors can significantly reduce the risk of thrombotic events.
**Correct Answer: D. Hemophilia**