Thrombocytopenia is not a feature of?
Correct Answer: Henoch schonlein purpura
Description: In Henoch-Schonlein Purpura laboratory studies generally show a mild leukocytosis, a normal platelet count, and occasionally eosinophilia. Serum complement components are normal, and IgA levels are elevated in about one-half of patients. Thrombotic Thrombocytopenic Purpura is characterized by a pentad of findings that include microangiopathic hemolytic anemia, thrombocytopenia, renal failure, neurologic findings, and fever. Findings to suppo the TTP diagnosis include an increased lactate dehydrogenase and indirect bilirubin, decreased haptoglobin, and increased reticulocyte count, with a negative direct antiglobulin test. Disseminated Intravascular Coagulation the common laboratory findings include the prolongation of PT and/or aPTT; platelet counts 100,000/L3, or a rapid decline in platelet numbers, the presence of schistocytes (fragmented red cells) in the blood smear and elevated levels of FDP (fibrin degradation products). The most sensitive test for DIC is the FDP level. In Cavernous angioma bleeding is usually of small volume, causing slight mass effect only. The bleeding risk for single cavernous malformations is 0.7-1.5% per year and may be higher for patients with prior clinical hemorrhage or multiple malformations. Ref: Harrison's Internal Medicine, 18th Edition, Pages 969, 978-80, 2797, 3299
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