Threonine is metabolised to:
**Core Concept**
Threonine is an essential amino acid that plays a crucial role in protein synthesis and is metabolized through various pathways. The metabolism of threonine involves its conversion to other amino acids, keto acids, and eventually, succinyl-CoA, which can enter the citric acid cycle.
**Why the Correct Answer is Right**
Threonine is metabolized through two main pathways: the direct pathway, where it is converted to alpha-ketobutyrate by threonine dehydrogenase, and the indirect pathway, where it is converted to glycine and acetyl-CoA by threonine aldolase and threonine dehydrogenase, respectively. However, the direct pathway is the primary route of threonine metabolism. Threonine dehydrogenase catalyzes the oxidation of threonine to alpha-ketobutyrate, which can then be converted to succinyl-CoA by the enzyme alpha-ketobutyrate dehydrogenase. Succinyl-CoA can enter the citric acid cycle, providing energy to the cell.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because threonine is not directly converted to aspartate. While aspartate can be synthesized from oxaloacetate, which can be derived from succinyl-CoA, threonine is not a direct precursor to aspartate.
**Option B:** This option is incorrect because threonine is not directly converted to glutamate. While glutamate can be synthesized from alpha-ketoglutarate, which can be derived from succinyl-CoA, threonine is not a direct precursor to glutamate.
**Option C:** This option is incorrect because threonine is not directly converted to glycine. While threonine can be converted to glycine through an indirect pathway involving threonine aldolase, this is not the primary route of threonine metabolism.
**Clinical Pearl / High-Yield Fact**
Threonine is an essential amino acid that cannot be synthesized by the human body and must be obtained through the diet. Deficiencies in threonine can lead to impaired protein synthesis and growth, particularly in children and individuals with certain medical conditions.
**Correct Answer:** D (succinyl-CoA)