Thiazolidinedione is associated with increasedrisk of?
Correct Answer: Hea failure
Description: Ans. is 'a' i.e., Hea failure Thiazolidinediones adverse effects Plasma volume expansion, edema, weight gain, headache, myalgia and mild anemia. Few cases of hepatic dysfunction and some cardiovascular events have been repoed - CHF may be precipitated - they are contraindicated in liver disease and in CHF. Rosiglitazone has been found to increase the risk of fracture, especially in elderly women. Glitazones with insulin can precipitate CHF - avoid such combination. These drugs prevent type 2 DM in prediabetics.
Category:
Pharmacology
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