Biochemistry Thiamine deficiency decreases cellular metabolism because: A Thiamine is a coenzyme for pyruvate dehydrogenase and alfa-ketoglutarate dehydrogenases B Activity of transketolase is inhibited C It is required for the process of transamination D It is a cofactor in oxidative reduction 💡 Explanation Thiamine deficiency decreases cellular metabolism because: ✓ Correct Answer: A. Thiamine is a coenzyme for pyruvate dehydrogenase and alfa-ketoglutarate dehydrogenases