Physostigmine was therapeuticallyused for the first time in treatment of glaucoma in 1877 by –
## Core Concept
Physostigmine is a cholinesterase inhibitor used in the treatment of glaucoma. It works by increasing the outflow of aqueous humor, thereby reducing intraocular pressure. Glaucoma is a condition characterized by increased intraocular pressure that can lead to optic nerve damage.
## Why the Correct Answer is Right
The correct answer, **Lagrange**, is credited with the first therapeutic use of physostigmine in 1877 for the treatment of glaucoma. Physostigmine's mechanism involves inhibiting acetylcholinesterase, the enzyme responsible for the breakdown of acetylcholine. This leads to an accumulation of acetylcholine in the synaptic cleft, stimulating muscarinic receptors in the eye and increasing the outflow of aqueous humor.
## Why Each Wrong Option is Incorrect
* **Option A:** Not provided, therefore cannot be evaluated.
* **Option B:** Not provided, therefore cannot be evaluated.
* **Option D:** Not provided, therefore cannot be evaluated.
## Clinical Pearl / High-Yield Fact
A key point to remember is that physostigmine is a reversible cholinesterase inhibitor and was one of the first drugs used to treat glaucoma. It highlights the historical development of glaucoma treatment and the importance of cholinergic pathways in managing the condition.
## Correct Answer Line
**Correct Answer: C. Lagrange**